chenodeoxycholic acid การใช้

• Chenodeoxycholic acid can be used in the treatment of cerebrotendineous xanthomatosis.
• Cholic acid and chenodeoxycholic acid are the most important human bile acids.
• Chenodeoxycholic acid and cholic acid are the two primary bile acids in humans.
• Some other mammals have muricholic acid or deoxycholic acid rather than chenodeoxycholic acid.
• Cholic acid is converted into deoxycholic acid and chenodeoxycholic acid into lithocholic acid.
• The two primary bile acids secreted by the liver are cholic acid and chenodeoxycholic acid.
• Chenodeoxycholic acid is made by many species, and is the prototypic functional bile acid.
• The product, a combination of bezafibrate with chenodeoxycholic acid, was invented in 2001.
• Its structure resembles chenodeoxycholic acid but with the 7-hydroxyl group in the ? position.
• Chenodeoxycholic acid is synthesized in the liver from cholesterol by a process which involves several enzymatic steps.
• As diarrhea is a complication of chenodeoxycholic acid therapy, it has also been used to treat constipation.
• The Australian biotechnology company Giaconda has tested a treatment for Hepatitis C infection that combines chenodeoxycholic acid with bezafibrate.
• Bacteria metabolize chenodeoxycholic acid into the secondary bile acid lithocholic acid, and they metabolize cholic acid into deoxycholic acid.
• Bile is naturally synthesized via cholesterol, consisting of compounds including taurochenodeoxycholic acid, ursodeoxycholic acid, and chenodeoxycholic acid.
• Unabsorbed chenodeoxycholic acid can be metabolised by bacteria in the colon to form the secondary bile acid known as lithocholic acid.
• To avoid the problems associated with the production of lithocholic acid, most species add a third hydroxyl group to chenodeoxycholic acid.
• He was instrumental in the development and evaluation of the use of bile acid therapy to dissolve cholesterol gallstones, first using chenodeoxycholic acid.
• However, they can sometimes be dissolved by increasing the concentration of certain naturally occurring bile acids, such as chenodeoxycholic acid and ursodeoxycholic acid.
• "' Glycochenodeoxycholic acid "'is a bile salt formed in the liver from chenodeoxycholic acid and glycine, usually found as the sodium salt.
• "' Taurochenodeoxycholic acid "'is a bile acid formed in the liver of most species, including humans, by conjugation of chenodeoxycholic acid with taurine.